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Author

Raghd Obidat

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Review Open access Oct 2026

Overview of screening assays used to evaluate PROTACs for cancer treatment.

Proteolysis-targeting chimeras (PROTACs) are promising anticancer agents, but optimizing them requires screening strategies that go beyond simple target-degradation readouts. This review provides an overview of assays for evaluating anticancer PROTACs and classifies them by their role in the degradation pathway, includ...

Raghd Obidat, Jazmin Reyes-Martinez, Sara Alrawashdeh et al. · 0 citations
#protein folding Open access Aug 2026

Ser715 Phosphorylation Induces β-Hairpin Unfolding and Destabilization of FOXM1 Autoinhibition.

A phosphorylation-triggered order-to-disorder transition that relieves FOXM1 autoinhibition and highlight Ser715 as a key structural and energetic switch is supported and provided a dynamic molecular framework for targeting FOXM1 activation via its regulatory fold.

Sara AlRawashdeh, Raghd Obidat, Aylin del Moral-Morales et al. · 1 citation

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