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Author

Rafał Bartoszewski

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Open access Sep 2026

Targeting biglycan–TLR2/TLR4 interaction with synthetic peptides mitigates inflammation and ameliorates renal function in ischemia–reperfusion injury

Renal ischemia–reperfusion injury (IRI), characterized by enhanced inflammation, is a leading cause of acute kidney injury (AKI) with limited treatments beyond supportive dialysis. Biglycan through toll-like receptors (TLR)2/TLR4 signaling aggravates tissue damage in acute renal IRI. This study aimed to identify the TL...

Rosetta Merline, L. T. Hsieh, Jinyang Zeng-Brouwers et al. · 0 citations
Open access Aug 2026

Priming Cells with Modulators of Cellular Signaling Ensures Enhanced Selectivity of HSPG-Specific Protein–Drug Conjugate Delivery

TriFHS-MMAE is reported, the first multivalent PDC specifically targeting heparan sulfate proteoglycans overexpressed by pancreatic cancer cells, which induces ultrafast and highly efficient aggregation-dependent endocytosis (ADE) of HSPGs.

Aleksandra Chorążewska, Krzysztof Ciura, M. Milczarek et al. · 0 citations

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