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Author

Rafaela Ribeiro

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Open access Oct 2026

PODXL regulates the neuronal entry of α-synuclein aggregates

Cell-to-cell transmission of α-synuclein (α-Syn) aggregates is a key event in Parkinson’s disease (PD) pathogenesis, yet the neuronal surface factors that govern uptake of pathogenic α-Syn fibrils remain undefined. We developed a flow cytometry-based CRISPR activation screen for modifiers of α-Syn preformed fibril (PFF...

Sandesh Neupane, Lea Šustić, Lorenzo Maraio et al. · 0 citations

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