Review
Aug 2026
Structural and single-molecule insights into the core human mitochondrial DNA replisome
Abstract Replication of human mitochondrial DNA (mtDNA) is essential for the maintenance of oxidative phosphorylation and cellular energy homeostasis. Impairment of this process leads to mtDNA deletions, depletion, and point mutations that underlie a broad spectrum of mitochondrial diseases, as well as contributing to...
Ismael Plaza-G.A, S. Miguez-Amil, Allison M Hayes et al.
· Biochemical Journal · 0 citations