Author

Rachel K. Lex

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Oct 2026

Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion.

Although tumor protein p53 (TP53) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis, we found that p53 suppresses clonal expansion by limiting progenitor self-renewal. Integrating chromatin immunoprecipitati...

Qi-Wen Gan, Wei Li, Rachel K. Lex et al. · Science · 1 citation

Open access Oct 2026

Dysregulation of epithelial differentiation architecture underlies field cancerization in head and neck cancer

Head and neck squamous cell carcinoma (HNSCC) has exceptionally high recurrence rates, exceeding 50%, contributing to mortality and morbidity. This recurrence rate is proposed to be due to field cancerization, a phenomenon where tumor-adjacent “field” tissue that appears histologically normal harbors molecular changes...

Claire B. Mills, Yin Huang, Chan-Mi Lee et al. · bioRxiv · 0 citations