Rachel E. Klevit

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation

In numerous neurodegenerative diseases known collectively as tauopathies, the microtubule‐associated protein tau forms fibrillar aggregates that are hallmarks of disease pathology. Tauopathies represent a substantial fraction of diseases associated with protein misfolding. Cellular chaperones known as small heat shock...