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Rachel A. Johnson

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Open access Sep 2026

Conformational reprogramming of c-Myc via intracellular cyclisation

It is shown that intracellular covalent cyclisation can conformationally reprogram the intrinsically disordered c-Myc bHLHZip region into a more ordered, DNA-binding state independent of its obligate partner Max, demonstrating that intracellular chemical constraint can provide access to structured states that are norma...

Rachel A. Johnson, Jody M. Mason · 0 citations

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