People with HIV (PWH) develop neurocognitive impairment despite control of viral infection. Key pathological features of NeuroHIV patients, including activated microglia, neuronal damage and behavioral impairment, are present in transgenic mice expressing HIV-1 envelope glycoprotein gp120 in their brain (HIVgp120tg). H...
Deepika Bhullar, Ricky Maung, Amanda J. Roberts et al.· Brain, behavior, and immunit...· 0 citations
MYC-driven (MYC+) cancers are highly aggressive and often fatal. MYC dysregulation is a key event in these cancers, yet MYC overexpression alone is often insufficient to initiate or sustain tumorigenesis. Plasmocytoma variant translocation 1 (PVT1), a long noncoding RNA (lncRNA) adjacent to MYC on chromosome 8q24, is f...
Ashutosh Tiwari, Utkarsha Paithane, K. Tashiro et al.· Genes & Development· 0 citations
Conservation of SAA1-TLR4 signaling in human skeletal muscle identifies a therapeutically actionable tumor–host pathway and demonstrates that host deterioration can be targeted independently of tumor progression.
Gabriele Guarnaccia, Jimmy Massenet, Alessandra Cecchini et al.· bioRxiv· 0 citations
It is shown that mitochondrial metabolism provides a second layer of control that enables execution of the inflammatory programme, and a mechanism that selectively controls the inflammatory output of senescent cells is revealed.
Hélène Martini, Jodie Birch, Francisco D M Marques et al.· Nature· 3 citations
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