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Author

Ravichandra Venkateshappa

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Review Open access Oct 2026

Clinical trials in a dish: cardiometabolic drug development with biological and digital twins

Preclinical drug development has long relied on animal models to predict safety and efficacy before agents enter human trials, despite critical differences between human and animal model physiology. The withdrawal of rosiglitazone, rofecoxib, and terfenadine due to cardiovascular toxicity exemplifies the translational...

Debarun Patra, Ibrahim M. Sayed, R. Venkateshappa et al. · 0 citations

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