Motivation Data-independent acquisition mass spectrometry (DIA-MS) has become increasingly popular for clinical proteomics due to its sensitivity and reproducibility. Univariate statistical analysis tools, such as limma and MSstats, are widely used for identifying differentially abundant proteins but cannot capture mul...
Daniel Byrne, M. McNamara, R. Unwin· bioRxiv· 0 citations
The incidence of endometrial cancer is rising globally, placing significant burden on diagnostic pathways for women with abnormal uterine bleeding. Current evaluation relies primarily on transvaginal ultrasound followed by invasive endometrial visualisation and sampling, although most symptomatic women have no sinister...
Molly Dore, Jiexin Cao, Holly Baker-Rand et al.· British Journal of Cancer· 0 citations
This work illustrates an initial step toward improving protein quantification starting at the spectral library level by filtering precursors which are poor quantitative representatives of their parent proteins, which could enable development of universal tissue-specific refined spectral libraries able to improve quanti...
Bethany A. Barnes, Haneen Alharbi, R. Unwin· bioRxiv· 0 citations
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