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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

R. Tampé

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Open access Aug 2026

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

ABSTRACT Conformational plasticity allows class I viral fusion proteins, including the SARS‐CoV‐2 spike, to undergo major structural rearrangements that support receptor binding and membrane fusion, making them key vaccine and antiviral targets. Using high‐speed atomic force microscopy (AFM) and single‐molecule force s...

Sarah Stainer, Rong Zhu, Manuel Reithofer et al. · 0 citations
Open access Sep 2026

Kinetic asymmetry drives directionality in an ATP-binding cassette transporter

Two conserved ionic locks within the nucleotide-binding domains that govern transition barriers and energy transduction are identified: an intra-subunit inward-facing (IF)-lock and an inter-subunit outward-facing (OF)-lock.

Michael Rudolph, Hossein Batebi, Malavika Pramod et al. · 0 citations
#protein folding Open access Aug 2026

Reconstitution of glycan-driven MHC-I recycling reveals calreticulin as mediator between TAPBPR and tapasin.

A glycan-dependent chaperone network is defined, finely tuned by a combination of low-micromolar interactions between the constituents, that ensures efficient MHC-I maturation and illustrates fundamental principles of ER protein quality control.

Tim J. Heinke, Amin Fahim, Niko Popovic et al. · 0 citations

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