Review
Open access
Aug 2026
The role of notch signaling in tumor angiogenesis in hematological malignancies
The evolutionarily conserved Notch signaling pathway is a contact-dependent communication mechanism regulating cell fate, tissue patterning, and cellular metabolism. Beyond canonical NICD-RBPJ transcription, Notch engages in non-canonical crosstalk with networks like Wnt and NF-κB. In tumor angiogenesis, the endothelia...
R. Tamma, V. Benagiano, Domenico Ribatti
· Frontiers in Oncology · 0 citations