A Five-Control Specificity Checklist Overturns an Apparent Phytochemical Disruptor of the VDAC1-Hexokinase-I Interface
Hexokinase-I anchors to voltage-dependent anion channel 1 (VDAC1) at a membrane-buried glutamate, E73, and disrupting this contact is an established anticancer objective. The site-directed docking of natural product libraries into such hotspots routinely identifies disruptors, yet these candidates are rarely tested for...