Author

R. Stanley

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Open access Sep 2026

Host soluble inositol phosphate signaling promotes coronavirus replication

Coronaviruses rely extensively on host pathways for replication, making host-directed therapies an attractive strategy for broad-spectrum antivirals with reduced risk of viral resistance. Here we identify the host soluble inositol phosphate pathway as a previously unrecognized dependency for coronavirus infection. Gene...

Igor Shats, Huan-Chen Wang, Yu-Bai Zhou et al. · bioRxiv · 0 citations

Open access Sep 2026

Structural insights into RNA phosphorylation by the RNase PNK module of the human rixosome complex.

An updated model for how the rixosome integrates its diverse enzymatic activities to regulate ITS2 processing is established and the human 5'-3' exoribonuclease XRN2 directly associates with RNase PNK and selectively degrades NOL9-phosphorylated RNA in vitro, thereby linking ITS2 processing by the rixosome to processiv...

Jacob Gordon, Savannah M. Seely, Huan-Chen Wang et al. · Nucleic Acids Research · 0 citations