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R. Spreng

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Open access Sep 2026

Longitudinal changes in control energy of brain networks in older adults at familial risk for Alzheimers disease

The ability of structural brain networks to control neural dynamics is affected by healthy and pathological aging, including Alzheimer’s disease (AD). According to network control theory, transitions between functional brain states incur energetic costs. How these costs change longitudinally with aging remains unknown....

Paulina Skolasinska, Alfie R. Wearn, Daniel W. O'Sullivan et al. · 0 citations
Open access Sep 2026

State-dependent signal flow hierarchy in the human cerebral cortex.

This study indicates that macroscale directed functional connectivity can reveal biologically grounded, state-dependent principles of signal flow in the human brain.

Younghyun Oh, Yejin Ann, Jae-Joong Lee et al. · 0 citations
Open access Jul 2026

Parent-of-origin effects in Alzheimer’s liability dissociate neurocognitive and cardiovascular traits in at-risk individuals

Summary Alzheimer’s disease (AD) has a higher prevalence in women than men and is more frequently inherited from mothers than fathers. Yet, while neuroimaging and biomarker studies link maternal family history to stronger AD-related alterations, epidemiological studies suggest that paternal history confers comparable o...

Chloé Savignac, Frédéric St-Onge, S. Villeneuve et al. · 0 citations

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