Open access
Oct 2026
Innovative Approach Reveals How Receptors Control G Protein State Equilibria
ABSTRACT G protein‐coupled receptors (GPCRs) constitute the largest family of drug targets, acting through heterotrimeric G proteins. Agonist bound GPCRs promote GDP release from G proteins allowing their activation upon GTP binding. Here, we analyze this process with innovative tools that detect the main states of nat...
Alexandre Bouyssou, Melinda Diniz da Silva, Julien Soulé et al.
· Advancement of science · 0 citations