R. Sorrentino

Ceramidase is involved in metabolic reprogramming of fibroblasts under hypoxia conditions

Physiological metabolic reprogramming is a cells strategy to resist/counteract stress to preserve homeostasis. Hypoxia is an important stress stimulus that can promote tissue remodeling and fibrosis, in which alterations in sphingolipid metabolism may contribute to fibroblast responses. Here, we investigated the po...