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Author

R. Snijder

2 papers indexed here

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Open access Oct 2026

Treatment patterns among US patients with muscle-invasive bladder cancer (MIBC) undergoing radical cystectomy (RC) during 2021–2024: Retrospective cohort study using the IQVIA database.

702 Background: MIBC is an aggressive disease with suboptimal patient (pt) outcomes. Neoadjuvant (NADJ) and adjuvant (ADJ) therapies have demonstrated improved survival when added to radical cystectomy (RC), but their use in the real-world remains limited. This study described recent real-world treatment patter...

Ronald C. Chen, Kimberly Donnowitz, D. Hauberg et al. · 0 citations
Clinical trial Open access Oct 2026

The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trial

Phosphatidylinositol 3-kinase delta (PI3Kδ) promotes tumour cell growth directly or indirectly by activating immune-suppressive cells. In contrast to previous PI3Kδ inhibitors, roginolisib is a selective, non-ATP competitive inhibitor, which locks PI3Kδ into an inactive state and causes an allosteric modulation. In a F...

A. D. Di Giacomo, M. Simonelli, A. Losurdo et al. · 2 citations

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