Background/Objectives: Diffuse midline gliomas (DMGs) are among the most aggressive paediatric brain tumours, with the pathognomonic H3K27M mutation present in over 80% of cases. This mutation drives epigenetic dysregulation and transcriptional reprogramming, yet its impact on the tumour antigenic landscape remains poo...
Tima Shamekhi, B. Zeng, C. Sun et al.· Cancers· 0 citations
Summary Despite ribosomal protein loss correlating with increased tumor predisposition, direct mechanisms for the counterintuitive oncogenic effect of ribosomal protein depletion have not been reported. We used genetic models to investigate ribosomal protein S19a (RpS19a) depletion in the Drosophila blood organ, the ly...
Naomi C. Mitchell, Arjun S. Chahal, T. Javaid et al.· iScience· 0 citations
These experiments revealed the intimate and necessary involvement of a histidine residue within the pentapeptide substrate of RufO in supporting effective nitration, with the protonation state of the intermediate compound II proposed to influence the production of nitrated tyrosine over unwanted nitrate formation.
Alicia M. Kirk, Jemma Gullick, Yong-Wei Zhao et al.· Journal of the American Chem...· 2 citations
This study repurposed a machine learning algorithm to comprehensively chart the biosynthetic space of the biarylitides, including variation of precursor motifs, P450, and additional modifying enzymes, which yielded 277 biarylitide biosynthetic gene clusters (BGCs).
Leo Padva, Jemma Gullick, Friederike Biermann et al.· JACS Au· 1 citation
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