R. Sadia

OmicSync: Reliability-Aware Spatial Multi-Omics Clustering with Evidence-Constrained LLM Reasoning

OmicSync is presented, a reliability-aware spatial multi-omics framework that couples unsupervised domain clustering with evidence-constrained LLM reasoning using model-derived per-spot signals, including assignment confidence, epistemic routing uncertainty, and modality-routing weights, and OmicSync-R is introduced, which closes the reasoning-clustering loop by using automatically computed reasoning-quality scores as REINFORCE rewards.