Evidence is provided that a single intranasal dose of LMNSC01 can reprogram chronic neuroimmune and neurovascular dysfunction after TBI in both sexes and supports the translational development of non-invasive intranasal LMNSC01 therapy for TBI.
Brecken Enright, Jeffrey P. Cheng, V. Adhikarla et al.· bioRxiv· 0 citations
Background/Objectives Cancer survivors frequently experience long-term neurocognitive impairments following chemotherapy and cranial irradiation, yet experimental models that enable mechanistic investigation of therapy-induced neurotoxicity at the transcriptional level remain limited. This study aimed to develop a huma...
Lance G. A. Nunes, Isabella Vasquez, Brecken Enright et al.· bioRxiv· 0 citations
This work developed an integrated experimental and computational pipeline for protein-level cell annotation and applied it to human PBMCs as an immune-cell test case, delivering an analytically benchmarked SCP workflow that resolves immune lineage and cell-state heterogeneity in human PBMCs and provides a classifier-re...
S. O'Connor, Romell B. Gletten, Ritin Sharma et al.· bioRxiv· 1 citation
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