Meiotic recombination is a fundamental process that generates genetic diversity by creating new combinations of existing alleles1. Whereas crossovers in humans are well characterized2, the more frequent non-crossovers that lead to gene conversion remain challenging to study. Here we show that single high-fidelity long...
Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune system to cancer. To inform understanding of somatic evolution in the human body we report the mutation rates and mutational...
M. H. Pham, L. M. R. Harvey, Thomas R. W. Oliver et al.· bioRxiv· 0 citations
Paternal de novo disease risk is shaped primarily by universal age-associated mutation and selection, while early mosaicism creates uncommon but clinically important high-risk individuals.
M. Neville, S. Neuser, R. Sanghvi et al.· Cell Genomics· 0 citations
Spatial transcriptomics maps gene expression at cellular resolution, revealing how cells organize into multicellular niches. Yet computational analyses remain dataset-specific, without a transferable representation of tissue organization that generalizes across datasets, tasks and tissues or predicts how tissues behave...
Sebastian Birk, M. V. Sanian, Amirhossein Vahidi et al.· bioRxiv· 4 citations· ⚡1
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
