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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

R. Prinjha

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2 papers indexed here

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Sep 2026

Differential BET protein recruitment to IL6 and IL8 promoters and suppression of inflammatory and cell cycle genes by BET inhibitor in keratinocytes.

Bromodomain containing BET proteins are druggable proteins which bind acetylated chromatin and are implicated in dysregulated gene expression in chronic inflammatory disorders. We set out to test whether BET proteins regulate inflammatory responses in keratinocytes, which are key effector cells in cutaneous inflammatio...

Keith C. P. Wu, N. Harker, S. Cockell et al. · 0 citations
Jul 2026

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

It is shown that DNMT1 is enriched at unmethylated CpG islands of actively transcribed genes largely by its CXXC domain, and RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promoting the suppression of endogenous retroviral element-dependent viral mimicry.

Brian J. Liddicoat, Jesse J. Balic, W. Jia et al. · 1 citation

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