R. Piper

Multi-centre validation of MELD-graph for automated focal cortical dysplasia detection using 7T compared to paired 3T MRI

Background: Software tools can support MRI diagnosis of focal cortical dysplasias (FCDs) - subtle, surgically-treatable lesions that underlie drug-resistant focal epilepsy (DRFE). MELD-graph, a widely used open-source tool combining surface-based morphometry with a convolutional neural network, was developed using 1.5T...

Spectrally-resolved transfer entropy in resting-state SEEG reveals epileptogenic and non-epileptogenic communication in adults and children with refractory epilepsy

Objective. To characterise directed, frequency-resolved communication between seizure onset zone (SOZ) and non-involved zone (NIZ) regions in resting-state stereo-electroencephalography (SEEG) from adults and children with drug-resistant epilepsy (DRE). Approach. We analysed retrospective SEEG from 21 adults and 18 pae...

Diffusion MRI abnormalities localise the epileptogenic zone in paediatric drug-resistant epilepsy

Opposing associations of default mode network and subcortical network efficiency with IQ in children with drug-resistant epilepsy.

Exploratory mediation analyses suggested that opposing DMN and Subcortical Network effects partially accounted for the observed group difference in IQ, highlighting opposing regional, rather than global, network alterations as candidate correlates of IQ variability in paediatric DRE.

Automated hippocampal sclerosis detection, using AID-HS, shows robust performance across multi-centre paired 7T and 3T MRI

Background: Hippocampal sclerosis (HS) is a common cause of drug-resistant focal epilepsy (DRFE) and amenable to neurosurgical treatment. Detection relies on MRI but can be challenging. 7 Tesla (T) ultra-high field MRI and automated MRI post-processing tools have independently been shown to improve radiological diagnos...