R. Omer

Emerging analytical techniques for tamoxifen and metabolite quantification in diverse matrices.

Tamoxifen (TMX), a key selective estrogen receptor (ER) modulator used in hormone-dependent breast cancer therapy, undergoes extensive metabolism to produce active metabolites, including endoxifen (END), 4-hydroxytamoxifen (4HT), and N-desmethyltamoxifen (NDT). The simultaneous determination of these compounds across p...

Hypothyroidism and Metabolic Dysfunction–Associated Steatotic Liver Disease: Mechanisms, Clinical Links, and Therapeutic Implications

Circulating Oxidative Stress and Antioxidant Biomarkers in Epilepsy: Temporal Changes at 1 and 2 h After Seizures

Health Risk Assessment Associated with Diesel Induced SO₂ Emissions in Erbil City: A Box Model Estimation.

Diesel with high sulfur content is a major contributor to sulfur dioxide (SO₂) emissions in urban environments, posing health risks to populations residing near high-traffic roads. This study investigated the influence of diesel sulfur content on SO₂ exposure and the associated non-carcinogenic health risks in resident...

The Redox Imbalance in Cancer: Targeting Glutathione and Thioredoxin Systems to Enhance Chemotherapy Response

Comprehensive evaluation of analytical methods for determination of ansamycins across diverse matrices.

Ansamycins (ANs), including rifampicin (RIF), rifabutin (RFB), rifapentine (RPT), rifalazil (RFL), and rifaximin (RFX), are structurally distinctive macrocyclic antibiotics whose analytical determination is complicated by very low systemic exposure (especially RFX), high protein binding and intracellular sequestration...

Sucralose and Human Health: Metabolic, Microbiome, Neuroendocrine, Toxicological, and Environmental Perspectives

Sucralose is a prevalent non-nutritive sweetener characterised by its chemical stability, intense sweetness, and low-calorie content, which have facilitated its global acceptance, regulatory endorsement, and an acceptable daily intake (ADI) of 5 mg/kg. However, recent data question its presumed inertness and undersco...

Analytical determination of meloxicam and tenoxicam: matrix-dependent challenges, emerging technologies, and sustainable future perspectives.

Future progress should shift from isolated improvements in detection sensitivity toward matrix-adaptive, digitally assisted, sustainability-aware analytical systems that integrate automated sample preparation, intelligent data interpretation, robust validation, and lifecycle-based performance assessment.

Saccharin Revisited: Chemistry, Metabolism, Toxicology and Human Health Risk Assessment in the Era of Evidence-Based Food Safety.

A comprehensive and critical synthesis of current knowledge on saccharin, encompassing its chemical characteristics, physicochemical properties, industrial and pharmaceutical applications, absorption, metabolism, excretion and toxicological profile is provided.

Dyslipidaemia: Pathophysiology, Epidemiology, Diagnostic Advances, and Emerging Therapeutic Strategies

This review elucidates the complex pathophysiology, epidemiological dynamics, and genetic architectures defining dyslipidaemia, delineating primary hereditary molecular defects from secondary acquired etiologies and discusses persistent barriers to patient adherence and the transformative potential of precision medicin...

AI-assisted sustainable pharmaceutical bioanalysis: critical review of LC-MS, matrix effects, and white analytical chemistry.

This critical review comprehensively evaluates the current state of pharmaceutical bioanalysis by examining emerging LC-MS technologies, sustainable analytical strategies, and the growing role of artificial intelligence (AI) and machine learning (ML) in analytical optimization, spectral interpretation, biomarker discov...

In silico evaluation of novel metabolites from Tricholoma pardinum: Insights into drug-likeness, toxicity and target interactions via molecular docking and dynamics.

Six previously uncharacterized metabolites isolated from the poisonous mushroom Tricholoma pardinum are investigated using an integrated in silico approach to evaluate their therapeutic potential, highlighting the potential of metabolites from T. pardinum as novel scaffolds for developing anticancer agents targeting PA...