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Open access Sep 2026

Skeletal pathologies caused by PLS3 inactivation are predominantly associated with impaired cortical bone integrity.

The identification of pathogenic PLS3 variants in individuals with X-linked osteoporosis (XLO) has demonstrated the importance of the actin-bundling protein plastin-3 for skeletal integrity. We and others have previously reported that Pls3-deficient mice display a skeletal phenotype that unexpectedly affects only the c...

O. Windels, A. Simon, Lara Schiewek et al. · 0 citations
Open access Jul 2026

Atypical Femoral Fractures in Adult Patients with Classical Osteogenesis Imperfecta

The findings suggest that AFF are not exclusively related to antiresorptive therapy but may be influenced by disease-specific factors, particularly the underlying collagen defect, femoral deformities and altered biomechanics.

Mikolaj Bartosik, O. Windels, F. Barvencik et al. · 0 citations

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