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Author

R. Nuon

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Open access Oct 2026

Semaglutide reduces volume overload and atrial remodelling in a novel experimental model of cardiometabolic HFpEF

Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent cardiometabolic syndrome linked to obesity, type 2 diabetes, and hypertension. Recent trials, including STEP-HFpEF1 and SUMMIT2, demonstrate that glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve outcomes in obese HFpEF...

J. Thomas, S. Bailey, R. Nuon et al. · 0 citations
Open access Aug 2026

Tissue-specific metabolomics in experimental HFpEF reveals hepatic remodelling modulated by SGLT2 inhibition

It is suggested that extra-cardiac metabolic pathways, particularly liver-centered mechanisms, may contribute to the therapeutic benefits of SGLT2 inhibitors in HFpEF and provide new insights into inter-organ metabolic regulation.

M. Kiyar, Ruth R Magaye, Shanae Bailey et al. · 0 citations

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