Author

R. Noberini

3 papers indexed here

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Open access Sep 2026

Cell-cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

The relationship between cell cycle length and differentiation competence has been studied in developmental biology, particularly in embryonic stem cells, which show a very short G1 phase required to maintain pluripotency. How and whether this principle operates in cancer— where the cell cycle is deregulated and G1 is...

K. Hayatigolkhatmi, R. Valzelli, E. Ceccacci et al. · bioRxiv · 0 citations

Open access Oct 2026

Establishment of Uveal Melanoma Patient-Derived Organoids Using an Air–Liquid Interface System for Translational Research

Purpose Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with a unique genetic and epigenetic profile and a high metastatic risk. The lack of experimental models to replicate tumor biology, including its epigenetic landscape, limits progress in translational research. Recently, patient-d...

Leticia Ussem, Karin U. Loeffler, Verena Tischler et al. · Investigative Ophthalmology... · 0 citations

Open access Sep 2026

Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity

Chemotherapy resistance and disease relapse are major determinants of treatment failure in acute myeloid leukemia (AML). Therapy-induced senescence (TIS) is one outcome of chemotherapy, but its immunological consequences in AML remain unclear. Here we show that ex vivo chemotherapy induces senescence in a subset of the...

Diego Gilioli, Simona Fusco, Teresa Tavella et al. · Nature Communications · 0 citations