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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

R. Nencka

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Open access Sep 2026

Characterization of the N7 RNA cap methyltransferase from Trichomonas vaginalis and inhibitor discovery

RNA cap formation is essential for eukaryotic gene expression, yet the enzymes responsible for cap methylation remain poorly characterized in many eukaryotic parasites, including Trichomonas vaginalis. Here, we functionally and structurally characterized the RNA guanine-N7 methyltransferases (MTases) from T. vaginalis,...

J. Benýšek, D. Chalupska, Milan Štefek et al. · 0 citations
Open access Aug 2026

First-in-class inhibitors of the protein lysine methyltransferase METTL21A.

A crystal structure of METTL21A is solved in complex with 6m, providing structural insight into ligand recognition and supporting further structure-guided optimization and establishing a biochemically and structurally validated starting point for probing METTL21A function and a foundation for the development of cellula...

Hugo Kocek, Michal Vaško, M. Dejmek et al. · 0 citations

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