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Improved MDD-recurrence understanding is aimed at by studying these four selected perspectives in combination and prospectively during remission by studying different predictors of recurrence in combination.
Diurnal profiles of DHEAS and cortisol/DHEAS-ratio remain equally altered in between depressive episodes, and may predict future recurrence, which suggests they represent an endophenotypic vulnerability trait rather than a state-effect, which provides a new road to understand recurrent depression and its prevention.
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