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Author

R. Mihaylova

2 papers indexed here

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Review Open access Sep 2026

Chronic Myeloid Leukemia Beyond BCR::ABL1 Inhibition: Resistance Mechanisms and Emerging Therapeutic Modalities

The BCR::ABL1 fusion oncoprotein is the molecular hallmark and principal oncogenic driver of chronic myeloid leukemia (CML). Tyrosine kinase inhibitors (TKIs) have transformed CML into a largely manageable chronic disease, yet acquired resistance, persistence of leukemic stem cells (LSCs), and disease progression remai...

R. Mihaylova · 0 citations
Open access Sep 2026

Design, Synthesis, and Integrated In Silico and In Vitro Evaluation of Chloro-Substituted Salicylaldehyde Benzoylhydrazones as Anticancer Agents

Background: Building on earlier work with methoxy-, dimethoxy-, bromo-, and nitro-substituted salicylaldehyde benzoylhydrazones, we synthesized and evaluated new 4-chloro- and 5-chloro derivatives bearing an additional chlorine substituent on the hydrazide-derived phenyl ring to further explore the impact of halogenati...

B. Nikolova-Mladenova, R. Mihaylova, Stilyana Kostova et al. · 0 citations

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