The combination of the ATR inhibitor berzosertib with carboplatin demonstrated a lower ORR and more frequent ≥ grade 3 TrAEs compared with docetaxel + carboplatin in this heavily pretreated, biomarker-unselected mCRPC population.
A. Choudhury, C. Zhong, Wan-Ling Xie et al.· Cancer Research Communicatio...· 0 citations
IMPORTANCE
Cardiovascular disease (CVD) is a leading noncancer cause of death among patients with prostate cancer (PC). Population-based risk calculators do not account for treatment-related effects of androgen-deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPis), and they have not been validated...
A. Guha, Ana Barac, M. Ryan et al.· JCO Oncology Practice· 0 citations
This work developed and clinically validated the System for Enhanced Evaluation of Tumor Cells (SEE-TC), a deep learning approach for scalable, reproducible phenotyping of individual circulating cells that is the first fully automated AI approach to single-cell segmentation and CTC phenotyping.
M. Bootsma, M. Sharifi, J. Sperger et al.· Clinical Cancer Research· 0 citations
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