Author

R. Mars

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Sep 2026

Microbiome signatures linked to cancer and treatment adverse events in a real-world cohort.

The gut microbiome has emerged as a key contributor to cancer biology. Prior studies have focused on individual cancers and often overlook comorbidities, obscuring whether reported associations are specific to a cancer type. Here, we present findings from a real-world mixed-cancer cohort (Mayo Clinic Cancer Microbiome)...

Lu Yang, Vaidhvi Singh, Brent J. Gawey et al. · Cell · 0 citations

Open access Aug 2026

Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility

The intestinal epithelium is exposed to diverse combinations of microbiota-derived compounds; however, the mechanisms by which the host integrates these signals remain poorly defined. Studying two highly abundant microbial metabolites, we identified the purine metabolite hypoxanthine as an effector metabolite that dire...

Yang Xiao, T. Louwies, R. Mars et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Gut microbiome signatures during acute infection are associated with long COVID

ABSTRACT Background Long COVID (LC) manifests in 10%–30% of non-hospitalized individuals post-SARS-CoV-2 infection, leading to significant morbidity. The predictive role of gut microbiome composition during acute infection in the development of LC is not well understood, partly because of the heterogeneous nature of th...

I. Comba, R. Mars, Lu Yang et al. · Gut microbes · 0 citations