Author

R. Marmorstein

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Open access Sep 2026

Acetyl-CoA–dependent processes are preferentially supported by local metabolite synthesis

Using cell lines in which ACLY is localized to either compartment, it is found that ACLY in either location supports fatty acid synthesis and histone acetylation, yet compartment-localized ACLY enables finer control, providing more precise regulation.

Julianna G. Supplee, Pedro Costa-Pinheiro, Karl A. Wessendorf-Rodriguez et al. · Science Advances · 0 citations

Open access Aug 2026

Ligand-dependent interdomain rearrangements drive catalysis by acetyl-CoA synthetases.

Acetyl-coenzyme A synthetases convert ATP, acetate, and coenzyme A (CoA) into acetyl-CoA, a central metabolite that fuels lipid biosynthesis and regulates protein and RNA acetylation. ACS enzymes contain N- and C-terminal domains that coordinate a two-step ping-pong mechanism involving sequential adenylation and thioes...

Meng Li, Ming-Yang Zhou, R. Marmorstein · Structure · 0 citations

#protein folding Sep 2026

Tideglusib as a First-in-Class Chemical Probe for NatA: Identification, Mechanism, and Cellular Validation of an Allosteric, CoA-Dependent Inhibitor.

Tideglusib is established as a mechanistic chemical probe for NatA, NatA is revealed as a previously unrecognized molecular target for a promiscuous clinical-stage investigational compound, and a conceptual framework for exploiting catalysis-dependent adduct formation as a new strategy for acetyltransferase inhibitor d...

Youchao Deng, Zhuo-Jun Luo, Sarah M. Gardner et al. · ACS Chemical Biology · 0 citations