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Author

R. Manguso

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Open access Oct 2026

A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy

A fully human sequence-based cell therapy suicide switch based on the overexpression of Caspase-Activated DNase and its stoichiometric chaperone/inhibitor ICAD fused to a lenalidomide-inducible degron achieved long-term expression in primary human T cells without detectable leakiness, and deep drug-induced cell depleti...

Ditsa Sarkar, William Lin, Nelson H. Knudsen et al. · 0 citations
Oct 2026

Epigenetic Priming Sensitizes Metastatic Breast Cancer to Checkpoint Blockade by Rewiring the Tumor-Immune Microenvironment.

Work using metastatic mouse models shows that the antitumor response is multifactorial, comprising downregulation of myeloid-mediated CD8+ T-cell suppression along with increased B-cell and plasma cell activation, antibody production, and tertiary lymphoid structure (TLS) maturation.

Yaiza Senent, R. Manguso · 0 citations

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