FORMULATION AND PHYSICOCHEMICAL CHARACTERIZATION OF PACLITAXEL-LOADED PLGA NANOPARTICLES WITH ENHANCED SOLUBILITY AND IN VITRO ANTICANCER ACTIVITY
Objective: Paclitaxel is a widely used chemotherapeutic agent with extremely poor aqueous solubility (~0.3 µg/ml), which significantly limits its bioavailability and therapeutic efficacy. The present study aimed to develop and characterize paclitaxel-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles to enhance...