A Hybrid Mechanistic–Machine Learning Framework for Patient-Specific Thrombin Generation and Interpretable Prediction of Recurrent Venous Thromboembolism
Predicting recurrence after a first venous thromboembolism episode remains difficult: existing risk scores use few variables and generalize poorly, whereas machine learning often lacks mechanistic interpretability. We developed a hybrid framework combining an artificial neural network with a mechanistic model of the co...