This review summarizes current knowledge regarding the molecular biology of TTP and HuR, emphasizing their opposing functions in mRNA metabolism and cancer progression; discusses mechanisms regulating their expression, localization, phosphorylation, and RNA-binding activity; analyze cancer-specific evidence; and examines models in which both proteins are co-expressed or functionally interconnected.
R. Lotti, Tommaso Selmi, Alexis Grande et al.· Frontiers in Oncology· 0 citations
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