R. Krishnadas

Early intervention with clozapine: Is there a neurobiological critical period for treatment-resistant schizophrenia?

Clozapine is the most effective treatment for treatment-resistant schizophrenia, yet it is often introduced late. This article proposes a critical period hypothesis, arguing that clozapine is most effective when started during a stage of illness in which network plasticity and synaptic substrate are still partially pre...