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Review Oct 2026

Safety and early outcomes of external beam radiation therapy with low dose brachytherapy boost in patients with prostate cancer: A single institution experience.

PURPOSE To evaluate the safety and early oncologic outcomes of external beam radiation therapy (EBRT) combined with a low-dose-rate (LDR) brachytherapy boost in patients with intermediate- and high-risk prostate cancer, as contemporary real-world evidence remains limited. METHODS AND MATERIALS Investigators retrospec...

Z. El Kouzi, M. Rooney, A. Samman et al. · 0 citations
Meta-analysis Sep 2026

Overall survival in oncology phase III trials: an individual patient level meta-analysis (OPTIMA)

Abstract Designing phase III oncology trials to demonstrate overall survival (OS) superiority may be challenging due to sample size, follow-up time, resources, and costs as compared to trials evaluating intermediate endpoints, which may or may not be reliable surrogates of OS. In this study, we investigate at scale the...

A. Sherry, N. Meimoun, A. Miller et al. · 0 citations

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