Author

R. Konrat

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Open access Sep 2026

Modifications of Lysine Residues 294 and 311 Within the Microtubule-Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria.

This study helps to establish a mechanistic framework linking combinatorial lysine modifications to Tau dysfunction and highlights the utility of region-resolved structural approaches to decipher posttranslational modification-dependent equilibria in intrinsically disordered proteins.

Dominik P. Vogl, Mario Migotti, R. Konrat et al. · Angewandte Chemie · 0 citations

Open access Jul 2026

A Comprehensive 19F NMR Framework for Fragment-Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR.

The design and validation of a non-proprietary 19 F NMR screening library (OpenFL600) capable of probing diverse binding pockets, as demonstrated for RNA, G protein-coupled receptors, kinases, protein-protein interactions, and proteases is presented.

S. Rüdisser, Gabriela R. Stadler, G. Padroni et al. · Angewandte Chemie · 0 citations

Open access Aug 2026

The ZBTB16/CUL3/ROC1 ubiquitin ligase drives the degradation of pathogenic pendrin (SLC26A4) protein variants

A primary mechanism of SLC26A4 regulation in the inner ear and kidney and of SLC26A4 loss of function in Pendred syndrome and deafness DFNB4 is described and a atomistic model of the complete SLC26A4/ZBTB16/Cullin 3/RocI complex is provided in agreement with experimental results.

Florian Huber, E. Bernardinelli, Bassam G. Haddad et al. · Journal of Biomedical Scienc... · 0 citations