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Author

R. Kirchdoerfer

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Open access Sep 2026

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism

These findings establish a two-pronged mode of coronavirus polymerase inhibition by CMX521, and suggest a second inhibitory mechanism for CMX521 when the coronavirus polymerase is associated with the viral helicase.

Asif Rakib, Calvin J. Gordon, Thomas K. Anderson et al. · 0 citations
Open access Aug 2026

Structural and biochemical analysis of the IBV nsp15 endoribonuclease reveals the necessity of peripheral site residues for activity

Cryo-electron microscopy and biochemistry are used to characterize IBV nsp15’s interactions with RNA, demonstrating a preference for IBV nsp15 to cleave double-stranded RNA over single-stranded RNA and observing nsp15 hexamers with two double-stranded RNAs bound simultaneously.

Ena S. Tully, R. Kirchdoerfer · 0 citations

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