In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Abstract Background and Hypothesis Schizophrenia spectrum disorders (SSDs) produce severe symptoms, disability, and premature mortality, but only partially effective symptomatic treatments exist. Treatment development is impeded by lack of insight into disease mechanisms or objective biomarkers for clinical trials. Adv...
Mohini Ranganathan, Susan G. Jakob, F. Cerrato et al.· Schizophrenia bulletin· 0 citations
This study shows that integrating plasma proteomics with multi-organ imaging provides a comprehensive pan-organ imaging-proteomics map and reveals molecular pathways linking circulating proteins to human organ biology.
Zi-Rui Fan, J. Chirinos, Xiao-Chen Yang et al.· Nature Communications· 0 citations
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