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Author

R. Guo

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Open access Sep 2026

Targeting Polθ Helicase with RP-3467: Preclinical Validation and Clinical Response in a gBRCA1 ovarian cancer patient with an acquired PARPi resistance mutation in TP53BP1

It is demonstrated that RP-3467 potently suppresses Pol{theta} enzymatic activity, abrogates MMEJ, and disrupts mitotic DNA repair in HR-deficient (HRD) models, inducing synthetic lethality.

E. Rosen, Marie-Claude Mathieu, Gino B. Ferraro et al. · 0 citations
Aug 2026

The pan-tumor landscape, allelic status, and genomic complexity of SMARCA4 alterations.

SMARCA4 alteration class and allelic status define biologically and clinically distinct subsets of tumors and support incorporating allelic status and functional mutation class into patient selection strategies for emerging BRM-targeted therapies.

M. Repetto, M. Gormally, Jason Chang et al. · 0 citations

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