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Author

R. Giebelhaus

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Open access Sep 2026

A design of experiments approach to production of medicinal bioactives in Mitragyna speciosa (Korth.) Havil

In vitro propagation is a viable approach to produce bioactive compounds in kratom plants and the presence of similar specialized metabolite profiles in greenhouse and in vitro-grown kratom plants paves the way for further studies on biotechnological engineering and production of these valuable compounds.

R. Giebelhaus, P. Brown, M. Ali et al. · 0 citations
Open access Sep 2026

Non-target screening using fast comprehensive two-dimensional liquid chromatography-high-resolution mass spectrometry II: the mosaic workflow - development of a scalable and open-source non-target screening data processing workflow for LC×LC-HRMS and its application to wastewater effluent.

Comprehensive two-dimensional liquid chromatography-high-resolution mass spectrometry (LC × LC-HRMS) offers improved group-type separation and mass spectral quality than one-dimensional LC-HRMS, but its widespread adaption remains limited, partly, due to labor-intensive and non-scalable data-processing workflows. Here,...

O. M. Kronik, R. Giebelhaus, Jan H. Christensen et al. · 0 citations

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