R. Gan

The IKKε-GABPA axis regulates STING transcription to orchestrate antiviral immunity and inflammation.

Engineering a ribozyme with aminoacyl-tRNA synthetase activity

A ribozyme that can charge a tRNA with amino acids and discriminate between cognate and non-cognate tRNAs is of interest because an RNA with this ability may have been a critical for translation in the transition from the RNA world. In addition, it could provide a tool for incorporating non-canonical amino acids for bi...

Single-cell multi-omics reveals circulating B cell heterogeneity across diverse disease contexts

Introduction B cells play essential roles in adaptive immunity by producing antigen-specific antibodies and interacting with T cells. Single-cell RNA and BCR sequencing technologies have enabled high-resolution dissection of B cell heterogeneity across diverse disease contexts. Atypical B cells (ABCs) display complex a...