Bovine coronavirus (BCoV) is a major pathogen of cattle and the closest known ancestor of the human coronavirus OC43, yet how viral evolution reshapes spike protein structure and function remains poorly understood. Here, we combined comparative genomics, glycoproteomics, cryo-EM, and antigenic characterization to defin...
Haneen Tarabih, Jimmy Asiku, Y. Levi-Kalisman et al.· bioRxiv· 0 citations
Hepatitis C virus (HCV) remains a major global health challenge despite the availability of highly effective antiviral therapies, underscoring the need for a broadly protective vaccine. The envelope glycoprotein E2 is the principal target of neutralizing antibodies, yet the full repertoire of vulnerable epitopes and me...
A scalable and adaptable microbial biotechnology platform for the scalable recombinant production of highly toxic bacterial proteins based on transient intramolecular toxin neutralization and the integration of transient intramolecular neutralization with computational engineering is presented.
R. Fraenkel, Inbar Cahana, Tomer Sivan et al.· bioRxiv· 0 citations
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