A comprehensive proteomic and transcriptomic mapping study found porcine and human kidneys exhibit a profoundly altered biological profile during warm ex vivo perfusion.
The molecular profile of donor kidneys is extensively remodeled during NMP, creating an ex vivo state that diverges considerably from in vivo physiology, challenging the use of in vivo biomarkers for ex vivo assessment.
V. Lantinga, Y. Zuo, C. Jaynes et al.
· Kidney International · 0 citations