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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

R. Ebright

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2 papers indexed here

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Sep 2026

Abstract PR011: Digenic CRISPR screening identifies novel KRAS/FGFR combination therapies for pancreatic cancer

Adaptive signaling remains a major barrier to durable responses with targeted therapy in pancreatic ductal adenocarcinoma (PDAC), where oncogenic KRAS drives the vast majority of tumors. To identify clinically actionable resistance nodes, we developed RAS+, a digenic CRISPR knockout library that systematically interr...

R. Ebright, Yao He, Alan Zhang et al. · 0 citations
Open access Sep 2026

Context-specific genetic interaction mapping reveals combinatorial KRAS/FGFR dependence in pancreatic cancer

Oncogenic KRAS drives >90% of pancreatic ductal adenocarcinoma (PDAC), and the pan-RAS inhibitor daraxonrasib doubles overall survival, but adaptive and acquired resistance limit the depth and duration of responses. To systematically map combination vulnerabilities, we developed RAS+, a digenic CRISPR knockout library...

R. Ebright, Yao He, Alan Zhang et al. · 0 citations

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