Author

R. Darwish

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Open access Sep 2026

Integrated Bioinformatics Analysis of Amphotericin B Toxicity

Amphotericin B is a broad-spectrum antifungal agent widely used for the prevention of severe and invasive fungal infections. Despite incredible antifungal activity, its scientific use is severely limited by extremely negative results, mainly nephrotoxicity Previous studies have proven that amphotericin B-precipitated t...

R. Al-Suhaimat, Walhan Alshaer, R. Darwish · Biomedical & Pharmacolog... · 0 citations

Open access Sep 2026

Serum metabolomics identifies ganglioside dysregulation and pyruvate dehydrogenase complex–related metabolic disturbances in pediatric drug-resistant epilepsy

Despite advances in epilepsy management, the exact causes of epilepsy remain unclear, and diagnostic biomarkers are still lacking. Besides, about one-third of cases involve drug-resistant epilepsy (DRE). This study employed untargeted metabolomics to identify potential metabolic signatures in the sera of ped...

Eman Y. Abu-rish, Reem H. Almalki, Amira T. Masri et al. · Frontiers in Pediatrics · 0 citations